2,6-Difluorophenol → HCID 57919339, compound

Participants

Reaction Steps

In an analogous manner to the stepwise sequence outlined in intermediate 19, starting from 4,5-dichloro-2-(tetrahydropyran-2-yl)-2H-pyridazin-3-one (Intermediate 20) and 2,6-difluoro-phenol and alkylating with 2-bromo-3-(2,6-difluoro-phenyl)-propionic acid methyl ester (Intermediate 15) afforded 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(2,6-difluoro-phenyl)-propionic acid as a light yellow solid (1.35 g, 98% for the final step). 1H NMR (300 MHz, DMSO-d6) δ ppm 3.42 (d, J=7.6 Hz, 2H), 5.47 (t, J=7.6 Hz, 1H), 6.00 (d, J=2.7 Hz, 1H), 6.93-7.09 (m, 2H), 7.22-7.55 (m, 4H), 8.20 (d, J=2.7 Hz, 1H), 13.38 (br s, 1H).

Provenance & Evidence