HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoro-3-methylphenol → HCID 57919338, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoro-3-methylphenol | HCID 2774152 | — |
| Reactant | 4,5-Dichloro-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one | HCID 10729262 | — |
| Reactant | Methyl 2-bromo-3-cyclopentylpropanoate | HCID 57919172 | — |
| Product | HCID 57919338 | HCID 57919338 | — |
Reaction Steps
In an analogous manner to the stepwise sequence outlined in Intermediate 19, starting from 4,5-dichloro-2-(tetrahydropyran-2-yl)-2H-pyridazin-3-one (Intermediate 20) and 2,6-difluoro-3-methyl-phenol and alkylating with 2-bromo-3-cyclopentyl-propionic acid methyl ester (Intermediate 10) afforded impure 3-cyclopentyl-2-[4-(2,6-difluoro-3-methyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid as an oily light brown semi-solid (716.0 mg, 87% for the final step) and was used in Example 107.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258134B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-d842085d2fb7462f84074ee2e947e705 |
| Source note | uspto-grants-2012_09 |