反应详情

温度

25 °C

A solution of 1-(5-methyl-3-nitro-pyrazol-1-yl)-propan-2-one (500 mg, 2.9 mmol) in ethanol (15 ml) was treated with sodium borohydride (111 mg, 0.29 mmol). The reaction was stirred at 25° C. for 2.5 h. At this time, the reaction was poured onto water and was extracted into ethyl acetate. The organics were concentrated in vacuo to afford 1-(5-methyl-3-nitro-pyrazol-1-yl)-propan-2-ol (440 mg, 88%) which was used without further purification; ES+-HRMS m/e calcd for C7H11N3O3 [M+H+] 186.0873, found 186.0873.

1. additionAt this time, the reaction was poured onto water
2. extractionwas extracted into ethyl acetate
3. concentrationThe organics were concentrated in vacuo