2-Aminothiazole → HCID 44463247, compound

Participants

Reaction Steps

Using the method described in Example 1, 3-cyclopentyl-2-(6-oxo-4-phenoxy-6H-pyridazin-1-yl)-propionic acid (Intermediate 19) and thiazol-2-ylamine afforded 3-cyclopentyl-2-(6-oxo-4-phenoxy-6H-pyridazin-1-yl)-N-thiazol-2-yl-propionamide as a white solid (53.9 mg, 45.3%); ES+-HRMS m/e calcd for C21H22N4O3S [M+H+] 411.1486, found 411.1485. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.02-1.87 (m, 9H), 1.97 (m, 1H), 2.26 (m, 1H), 5.54 (dd, J=4.4, J=10.7 Hz, 1H), 5.57 (d, J=2.7 Hz, 1H), 7.23 (d, J=3.6 Hz, 1H), 7.30 (d, J=7.5 Hz, 2H), 7.37 (t, J=7.5 Hz, 1H), 7.49 (d, J=3.6 Hz, 1H), 7.53 (t, J=7.5 Hz, 2H), 8.16 (d, J=2.7 Hz, 1H), 12.55 (s, 1H).

Provenance & Evidence