1,3,4-Thiadiazole, 2-amino-5-methyl- → HCID 57919273, compound

Participants

Reaction Steps

Using the method described in Example 1, 3-cyclopentyl-2-(6-oxo-4-phenoxy-6H-pyridazin-1-yl)-propionic acid (Intermediate 19) and 5-methyl-[1,3,4]thiadiazol-2-ylamine afforded 3-cyclopentyl-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-2-(6-oxo-4-phenoxy-6H-pyridazin-1-yl)-propionamide as a white solid (60.1 mg, 31.4%); ES+-HRMS m/e calcd for C21H23N5O3S [M+Na+] 448.1414, found 448.1413. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.01-1.77 (m, 9H), 1.96 (m, 1H), 2.26 (m, 1H), 2.58 (s, 3H), 5.52 (dd, J=4.2, J=10.6 Hz, 1H), 5.73 (d, J=2.7 Hz, 1H), 7.28 (d, J=7.5 Hz, 2H), 7.35 (t, J=7.5 Hz, 1H), 7.52 (t, J=7.5 Hz, 2H), 8.14 (d, J=2.7 Hz, 1H), 12.82 (s, 1H).

Provenance & Evidence