3-cyclopentyl-2-[6-oxo-4-(4-trifluoromethyl-phenoxy)-6H-pyridazin-1-yl]-propionic acid → HCID 57919194, compound

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Reaction Steps

Using the method described in Example 1, 3-cyclopentyl-2-[6-oxo-4-(4-trifluoromethyl-phenoxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 23) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(4-trifluoromethyl-phenoxy)-6H-pyridazin-1-yl]-propionamide as a yellow solid (23.1 mg, 9%); ES+-HRMS m/e calcd for C26H30F3N5O4 [M+H+] 534.2323 found 534.2324. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.07 (m, 1H), 1.16-1.79 (m, 8H), 1.92 (m, 1H), 2.25 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.49 (dd, J=4.3, J=11.1 Hz, 1H), 6.01 (d, J=2.9 Hz, 1H), 6.40 (d, J=2.3 Hz, 1H), 7.53 (d, J=2.3 Hz, 1H), 7.53 (d, J=8.5 Hz, 2H), 7.90 (d, J=8.5 Hz, 2H), 8.16 (d, J=2.9 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence