HCID 57919281, compound → HCID 57919103, compound

Participants

Reaction Steps

Using the method described in Example 1, 3-cyclopentyl-2-[6-oxo-4-(3-trifluoromethyl-phenoxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 22) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(3-trifluoromethyl-phenoxy)-6H-pyridazin-1-yl]-propionamide as a white solid (13.7 mg, 5%); ES+-HRMS m/e calcd for C26H30F3N5O4 [M+H+] 534.2323 found 534.2323. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.07 (m, 1H), 1.27-1.77 (m, 8H), 1.92 (m, 1H), 2.25 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.48 (dd, J=4.4, J=11.0 Hz, 1H), 5.86 (d, J=2.9 Hz, 1H), 6.40 (d, J=2.2 Hz, 1H), 7.53 (d, J=2.2 Hz, 1H), 7.65 (m, 1H), 7.70-7.83 (m, 3H), 8.16 (d, J=2.8 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence