HCID 57919124, compound → HCID 44464554, compound

Participants

Reaction Steps

Using the method described in Example 1, 3-cyclopentyl-2-[4-(3-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 25) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(3-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as an off-white solid (14.6 mg, 10.1%); ES+-HRMS m/e calcd for C26H33N5O5 [M+Na+] 518.2374 found 518.2378. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.21-1.74 (m, 8H), 1.91 (m, 1H), 2.27 (m, 1H), 3.78 (s, 3H), 3.89 (s, 2H), 4.67 (s, 1H), 5.45 (m., 1H), 5.78 (br.s., 1H), 6.40 (s, 1H), 6.81-6.98 (m, 3H), 7.37-7.49 (m, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.11 (d, J=2.4 Hz, 1H), 10.81 (s, 1H).

Provenance & Evidence