HCID 57919111, compound → HCID 44466926, compound

Participants

Reaction Steps

Using the method described in Example 11, 3-cyclopentyl-2-[4-(2-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 24) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(2-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as a white solid (83.8 mg, 65%); ES+-HRMS m/e calcd for C26H33N5O5 [M+H+] 496.2555 found 496.2552. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.04 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.21-1.74 (m, 8H), 1.91 (m, 1H), 2.27 (m, 1H), 3.80 (s, 3H), 3.89 (s, 2H), 4.68 (s, 1H), 5.45 (dd, J=4.2, J=11.2 Hz, 1H), 5.56 (d, J=2.7 Hz, 1H), 6.39 (d, J=2.1 Hz, 1H), 7.00-7.11 (m, 1H), 7.20-7.31 (m, 2H), 7.31-7.41 (m, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.12 (d, J=2.7 Hz, 1H), 10.83 (s, 1H).

Provenance & Evidence