HCID 57919225, compound → HCID 57919251, compound

Participants

Reaction Steps

Using the method described in Example 11, 3-cyclopentyl-2-[4-(4-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 26) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(4-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as a white solid (40.3 mg, 26%); ES+-HRMS m/e calcd for C26H33N5O5 [M+H+] 496.2555 found 496.2554. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.19-1.78 (m, 8H), 1.91 (m, 1H), 2.28 (m, 1H), 3.79 (s, 3H), 3.89 (s, 2H), 4.67 (s, 1H), 5.46 (dd, J=4.0, J=11.1 Hz, 1H), 5.67 (d, J=2.8 Hz, 1H), 6.39 (d, J=2.3 Hz, 1H), 7.05 (d, J=9.1 Hz, 2H), 7.23 (d, J=9.1 Hz, 2H), 7.52 (d, J=2.3 Hz, 1H), 8.10 (d, J=2.8 Hz, 1H), 10.79 (s, 1H).

Provenance & Evidence