HCID 57919130, compound → HCID 57919131, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(3-fluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 42) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-2-[4-(3-fluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (0.74 g, 53%); ES+-HRMS m/e calcd for C25H30N5O4F [M+H+] 484.2355 found 484.2356. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.10 (m, 1H), 1.27-1.75 (m, 8H), 1.92 (m, 1H), 2.28 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.48 (dd, J=4.3, J=10.9 Hz, 1H), 5.88 (d, J=2.9 Hz, 1H), 6.40 (d, J=2.3 Hz, 1H), 7.17 (dd, Jm=2.3 Hz, Jo=8.3 Hz, 1H), 7.22 (td, Jm=2.3 Hz, Jo=8.3 Hz, 3JF=8.3 Hz, 1H), 7.31 (dt, Jm=2.3 Hz, 3JF=9.9 Hz, 1H), 7.53 (d, J=2.3 Hz, 1H), 7.57 (dt, Jo=8.3 Hz, 4JF=6.9 Hz, 1H), 8.13 (d, J=2.9 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence