HCID 57919189, compound → HCID 66893131, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(naphthalen-1-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 38) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(naphthalen-1-yloxy)-6-oxo-6H-pyridazin-1-yl]-octanoic acid [1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-amide as a white solid (0.15 g, 11%); ES+-HRMS m/e calcd for C29H33N5O4 [M+H+] 516.2606 found 516.2604. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.10-1.20 (br.s., 7H), 1.22-1.83 (m, 8H), 1.93 (m, 1H), 2.29 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.45 (m, 1H), 5.63 (s, 1H), 6.40 (s, 1H), 7.44-7.74 (m, 5H), 7.87-8.16 (m, 3H), 8.29 (s, 1H), 10.79 (s, 1H).

Provenance & Evidence