HCID 57919274, compound → HCID 57919256, compound

Participants

Reaction Steps

Using the method described in Example 17, 2-[4-(2-cyclohexyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-propionic acid (Intermediate 35) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(2-cyclohexyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (0.82 g, 62%); ES+-HRMS m/e calcd for C31H41N5O4 [M+H+] 548.3232 found 548.3233. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.17-1.84 (m, 18H), 1.94 (m, 1H), 2.27 (m, 1H), 2.61 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.47 (dd, J=4.1, J=10.7 Hz, 1H), 5.61 (d, J=2.7 Hz, 1H), 6.40 (d, J=2.1 Hz, 1H), 7.15-7.24 (m, 1H), 7.27-7.38 (m, 2H), 7.47 (dd, J=3.6, J=5.7 Hz, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.18 (d, J=2.7 Hz, 1H), 10.79 (s, 1H).

Provenance & Evidence