HCID 57919158, compound → HCID 44464303, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(2-cyclopentyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 36) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-2-[4-(2-cyclopentyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (1.03 g, 75%); ES+-HRMS m/e calcd for C30H39N5O4 [M+H+] 534.3075 found 534.3076. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.20-1.80 (m, 14H), 1.81-2.02 (m, 3H), 2.27 (m, 1H), 3.04 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.46 (dd, J=4.4, J=10.7 Hz, 1H), 5.59 (d, J=2.8 Hz, 1H), 6.40 (d, J=2.2 Hz, 1H), 7.19 (m, 1H), 7.27-7.37 (m, 2H), 7.49 (dd, J=3.6, J=5.7 Hz, 1H), 7.52 (d, J=2.2 Hz, 1H), 8.16 (d, J=2.8 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence