2-[4-(biphenyl-2-yloxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentylpropionic acid → HCID 57919181, compound

Participants

Reaction Steps

Using the method described in Example 17, 2-[4-(biphenyl-2-yloxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-propionic acid (Intermediate 37) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(biphenyl-2-yloxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (0.74 g, 50%); ES+-HRMS m/e calcd for C31H35N5O4 [M+H+] 542.2762 found 542.2759. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.02 (m, 1H), 1.04 (s, 3H), 1.05 (s, 3H), 1.26 (m, 1H), 1.36-1.66 (m, 7H), 1.88 (m, 1H), 2.15 (m, 1H), 3.88 (s, 2H), 4.66 (s, 1H), 5.37 (dd, J=4.4, J=11.0 Hz, 1H), 5.62 (d, J=2.9 Hz, 1H), 6.37 (d, J=2.3 Hz, 1H), 7.29-7.36 (m, 1H), 7.37-7.43 (m, 3H), 7.44-7.60 (m, 6H), 7.97 (d, J=2.9 Hz, 1H), 10.73 (s, 1H).

Provenance & Evidence