HCID 57919284, compound → HCID 57919235, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-(6-oxo-4-o-tolyloxy-6H-pyridazin-1-yl)-propionic acid (Intermediate 41) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-(6-oxo-4-o-tolyloxy-6H-pyridazin-1-yl)-propionamide as a white solid (0.86 g, 58%); ES+-HRMS m/e calcd for C26H33N5O4 [M+H+] 480.2606 found 480.2605. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.27-1.75 (m, 8H), 1.92 (m, 1H), 2.16 (s, 3H), 2.27 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.45 (dd, J=4.3, J=10.9 Hz, 1H), 5.56 (d, J=2.8 Hz, 1H), 6.40 (d, J=2.3 Hz, 1H), 7.21 (dd, Jo=7.5 Hz, Jm=1.3 Hz, 1H), 7.28 (td, Jo=7.5 Hz, Jm=1.3 Hz, 1H), 7.34 (td, Jo=7.5 Hz, Jm=1.3 Hz, 1H), 7.41 (d, Jo=7.5 Hz, 1H), 7.53 (d, J=2.3 Hz, 1H), 8.15 (d, J=2.8 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence