HCID 57919190, compound → HCID 57919100, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(2-methyl-pyridin-3-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 50) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(2-methyl-pyridin-3-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as an off-white solid (0.26 g, 18%); ES+-HRMS m/e calcd for C25H32N6O4 [M+H+] 481.2558 found 481.2556. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.09 (m, 1H), 1.27-1.74 (m, 8H), 1.92 (m, 1H), 2.28 (m, 1H), 2.38 (s, 3H), 3.89 (s, 2H), 4.67 (s, 1H), 5.47 (dd, J=4.4, J=10.8 Hz, 1H), 5.74 (d, J=2.9 Hz, 1H), 6.40 (d, J=2.1 Hz, 1H), 7.39 (dd, Jo=8.1 Hz, Jo=4.7 Hz, 1H), 7.53 (d, J=2.1 Hz, 1H), 7.73 (dd, Jo=8.1 Hz, Jm=1.3 Hz, 1H), 8.18 (d, J=2.9 Hz, 1H), 8.45 (dd, Jo=4.7 Hz, Jm=1.3 Hz, 1H), 10.81 (s, 1H).

Provenance & Evidence