3-cyclopentyl-2-[6-oxo-4-(2-pyrrolidin-1-yl-phenoxy)-6H-pyridazin-1-yl]propionic acid → HCID 44463245, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[6-oxo-4-(2-pyrrolidin-1-yl-phenoxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 51) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(2-pyrrolidin-1-yl-phenoxy)-6H-pyridazin-1-yl]-propionamide as a yellow solid (0.50 g, 34%); ES+-HRMS m/e calcd for C29H38N6O4 [M+H+] 535.3028 found 535.3027. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.08 (m, 1H), 1.25-1.73 (m, 8H), 1.83 (m, 4H), 1.93 (m, 1H), 2.25 (m, 1H), 3.22 (m, 4H), 3.89 (s, 2H), 4.67 (s, 1H), 5.44 (dd, J=4.5, J=10.7 Hz, 1H), 5.54 (d, J=2.9 Hz, 1H), 6.39 (d, J=2.3 Hz, 1H), 6.79 (m, 1H), 6.89 (dd, Jo=8.3 Hz, Jm=1.1 Hz, 1H), 7.09 (dd, Jo=7.9 Hz, Jm=1.5 Hz, 1H), 7.19 (m, 1H), 7.52 (d, J=2.3 Hz, 1H), 8.12 (d, J=2.9 Hz, 1H), 10.80 (s, 1H).

Provenance & Evidence