HCID 57919248, compound → HCID 57919202, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[6-oxo-4-(pyridin-3-yloxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 54) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(pyridin-3-yloxy)-6H-pyridazin-1-yl]-propionamide as an off-white solid (0.78 g, 53%); ES+-HRMS m/e calcd for C24H30N6O4 [M+H+] 467.2402 found 467.2399. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.11 (m, 1H), 1.26-1.75 (m, 8H), 1.92 (m, 1H), 2.29 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.48 (dd, J=4.4, J=11.0 Hz, 1H), 5.88 (d, J=2.8 Hz, 1H), 6.40 (d, J=2.3 Hz, 1H), 7.53 (d, J=2.3 Hz, 1H), 7.57 (dd, Jo=8.4, 4.7 Hz, 1H), 7.83 (ddd, Jo=8.4 Hz, Jm=2.8, 1.2 Hz, H), 8.17 (d, J=2.8 Hz, 1H), 8.58 (dd, Jo=4.7 Hz, Jm=1.2 Hz, 1H), 8.61 (d, Jm=2.8 Hz, H), 10.80 (s, 1H).

Provenance & Evidence