HCID 57919291, compound → HCID 44464306, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(2,5-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 46) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-2-[4-(2,5-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (0.76 g, 63%); ES+-HRMS m/e calcd for C25H29N5O4F2 [M+H+] 502.2261 found 502.2259. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.08 (m, 1H), 1.24-1.77 (m, 8H), 1.92 (m, 1H), 2.28 (m, 1H), 3.89 (s, 2H), 4.68 (s, 1H), 5.47 (dd, J=4.1, J=11.0 Hz, 1H), 6.00 (d, J=2.7 Hz, 1H), 6.40 (d, J=2.1 Hz, 1H), 7.24-7.35 (m, 1H), 7.53 (d, J=2.1 Hz, 1H), 7.53-7.62 (m, 2H), 8.21 (d, J=2.7 Hz, 1H), 10.84 (s, 1H).

Provenance & Evidence