HCID 57919123, compound → HCID 57919140, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(2-morpholin-4-yl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 53) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(2-morpholin-4-yl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as a white solid (0.61 g, 51%); ES+-HRMS m/e calcd for C29H38N6O5 [M+H+] 551.2977 found 551.2976. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.08 (m, 1H), 1.24-1.76 (m, 8H), 1.92 (m, 1H), 2.28 (m, 1H), 2.83-3.05 (m, 4H), 3.46-3.59 (m, 4H), 3.89 (s, 2H), 4.67 (s, 1H), 5.51 (dd, J=4.1, J=11.0 Hz, 1H), 5.74 (d, J=3.0 Hz, 1H), 6.39 (d, J=2.1 Hz, 1H), 7.09-7.18 (m, 2H), 7.25 (dd, Jo=7.8 Hz, Jm=1.5 Hz, 1H), 7.27-7.37 (m, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.02 (d, J=3.0 Hz, 1H), 10.77 (s, 1H).

Provenance & Evidence