HCID 57919146, compound → HCID 57919305, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[6-oxo-4-(3-phenoxy-phenoxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 49) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(3-phenoxy-phenoxy)-6H-pyridazin-1-yl]-propionamide as a white solid (0.63 g, 48%); ES+-HRMS m/e calcd for C31H35N5O5 [M+H+] 558.2711 found 558.2706. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.05 (s, 3H), 1.06 (s, 3H), 1.07 (m, 1H), 1.24-0-1.77 (m, 8H), 1.91 (m, 1H), 2.27 (m, 1H), 3.89 (s, 2H), 4.68 (s, 1H), 5.46 (dd, J=4.4, J=11.0 Hz, 1H), 5.89 (d, J=2.7 Hz, 1H), 6.39 (d, J=2.4 Hz, 1 Hr), 6.94 (m, 1H), 6.96 (d, Jm=1.5 Hz, 1H), 7.05 (m, 1H), 7.11 (dd, Jo=7.8 Hz, 2H), 7.19 (t, Jo=7.4 Hz, 1H), 7.38-7.55 (m, 4H), 8.10 (d, J=2.7 Hz, 1H), 10.79 (s, 1H).

Provenance & Evidence