HCID 57919137, compound → HCID 57919318, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[4-(isoquinolin-5-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 56) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[4-(isoquinolin-5-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionamide an off-white solid (0.56 g, 44%); ES+-HRMS m/e calcd for C28H32N6O4 [M+H+] 517.2558 found 517.2557. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.04 (s, 3H), 1.06 (s, 3H), 1.10 (m, 1H), 1.22-1.80 (m, 8H), 1.92 (m, 1H), 2.29 (m, 1H), 3.89 (s, 2H), 4.68 (s, 1H), 5.46 (dd, J=4.2, J=10.6 Hz, 1H), 5.76 (d, J=2.8 Hz, 1H), 6.40 (d, J=2.2 Hz, 1H), 7.52 (d, J=2.2 Hz, 1H), 7.73-7.85 (m, 3H), 8.16 (m, 1H), 8.30 (d, J=2.8 Hz, 1H), 8.58 (d, J=5.7 Hz, 1H), 9.47 (s, 1H), 10.86 (s, 1H).

Provenance & Evidence