HCID 57919098, compound → HCID 44464799, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[6-oxo-4-(quinolin-8-yloxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 55) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(quinolin-8-yloxy)-6H-pyridazin-1-yl]-propionamide as an off-white solid (0.34 g, 25%); ES+-HRMS m/e calcd for C28H32N6O4 [M+H+] 517.2558 found 517.2558. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.04 (s, 3H), 1.06 (s, 3H), 1.10 (m, 1H), 1.27-1.76 (m, 8H), 1.91 (m, 1H), 2.23 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.44 (dd, J=4.5, J=10.9 Hz, 1H), 5.50 (d, J=2.9 Hz, 1H), 6.40 (d, J=2.2 Hz, 1H), 7.52 (d, J=2.2 Hz, 1H), 7.65 (dd, Jo=8.3, 4.2 Hz, 1H), 7.72 (t, Jo=7.9 Hz, 1H), 7.76 (dd, Jo=7.5 Hz, Jm=1.5 Hz, 1H), 8.03 (dd, Jo=8.1 Hz, Jm=1.5 Hz, 1H), 8.24 (d, J=2.9 Hz, 1H), 8.52 (dd, Jo=8.3 Hz, Jm=1.7 Hz, 1H), 8.92 (dd, Jo=4.2 Hz, Jm=1.7 Hz, 1H), 10.81 (s, 1H).

Provenance & Evidence