HCID 57919304, compound → HCID 57919264, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-{6-oxo-4-[2-(pyrrolidine-1-carbonyl)-phenoxy]-6H-pyridazin-1-yl}-propionic acid (Intermediate 27) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-{6-oxo-4-[2-(pyrrolidine-1-carbonyl)-phenoxy]-6H-pyridazin-1-yl}-propionamide as a light yellow solid (24.6 mg, 19%); ES+-HRMS m/e calcd for C30H38N6O5 [M+H+] 563.2977 found 563.2974. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.03-1.08 (m, 7H) 1.25-2.03 (m, 13H) 2.19-2.40 (m, 1H) 3.21 (t, J=6.2 Hz, 2H) 3.28-3.36 (m, 2H) 3.89 (s, 2H) 4.67 (s, 1H) 5.47 (dd, J=11.1, 4.3 Hz, 1H) 5.79 (d, J=2.8 Hz, 1H) 6.40 (d, J=2.1 Hz, 1H) 7.38 (d, J=8.1 Hz, 1H) 7.41 (t, J=7.5 Hz, 1H) 7.49-7.54 (m, 2H) 7.54-7.61 (m, 1H) 8.07 (d, J=2.8 Hz, 1H) 10.80 (s, 1H).

Provenance & Evidence