HCID 57919155, compound → HCID 57919204, compound

Participants

Reaction Steps

Using the method described in Example 17, 3-cyclopentyl-2-[6-oxo-4-(3-trifluoromethyl-benzyl)-6H-pyridazin-1-yl]-propionic acid (Intermediate 64) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(3-trifluoromethyl-benzyl)-6H-pyridazin-1-yl]-propionamide as a white solid (43.7 mg, 63%); ES+-HRMS m/e calcd for C27H32N5O3F3 [M+H+] 532.2530, found 532.2526. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.03-1.08 (m, 1H) 1.04 (br s, 3H) 1.06 (br s, 3H) 1.17-1.73 (m, 8H) 1.90 (br s, 1H) 2.15-2.31 (m, 1H) 3.88 (s, 2H) 3.99 (s, 2H) 4.66 (s, 1H) 5.47 (dd, J=10.7, 4.4 Hz, 1H) 6.37 (d, J=2.1 Hz, 1H) 6.72 (s, 1H) 7.51 (d, J=2.1 Hz, 1H) 7.54-7.72 (m, 3H) 7.75 (s, 1H) 7.98 (d, J=2.1 Hz, 1H) 10.77 (s, 1H).

Provenance & Evidence