HCID 57919339, compound → HCID 44464796, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(2,6-difluoro-phenyl)-propionic acid (Intermediate 34) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(2,6-difluoro-phenyl)-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a light yellow solid (571 mg, 65%); ES+-HRMS m/e calcd for C26H23N5O4F4 [M+H+] 546.1759 found 546.1762. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.04 (s, 6H) 3.39-3.58 (m, 2H) 3.88 (s, 2H) 4.66 (s, 1H) 5.70 (dd, J=9.7, 5.6 Hz, 1H) 5.90 (d, J=2.7 Hz, 1H) 6.47 (d, J=2.1 Hz, 1H) 6.96 (t, J=8.0 Hz, 2H) 7.19-7.34 (m, 1H) 7.34-7.41 (m, 2H) 7.42-7.51 (m, 1H) 7.54 (d, J=2.1 Hz, 1H) 8.20 (d, J=2.7 Hz, 1H) 10.67 (s, 1H).

Provenance & Evidence