N-(2-aminoethyl)acetamide → N-[2-(2-chloro-5-iodopyrimidine-4-ylamino)ethyl]acetamide

Participants

Reaction Steps

In analogy to GP 2 reaction of 2,4-dichloro-5-iodopyrimidine (1.0 g, 3.6 mmol) with N-(2-aminoethyl)acetamide (e.g. ABCR, Aldrich) (0.42 mL, 3.9 mmol) provided the desired product in 71% yield (878 mg) after trituration of the crystals obtained with diethyl ether.

Provenance & Evidence