HCID 57919282, compound → HCID 66894174, compound

Participants

Reaction Steps

Using the method described in Example 49, 3-cyclobutyl-2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 29) and 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine (Intermediate 3) afforded N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-3-cyclobutyl-2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as an off-white solid (342.2 mg, 40%); ES+-HRMS m/e calcd for C28H37N5O4SiF2 [M+H+] 574.2656 found 574.2656. 1H NMR (400 MHz, DMSO-d6) δ ppm −0.07 (s, 6H) 0.80 (s, 9H) 1.49-1.67 (m, 1H) 1.68-2.02 (m, 5H) 2.03-2.30 (m, 3H) 3.86 (t, J=5.2 Hz, 2H) 4.06 (t, J=5.2 Hz, 2H) 5.28-5.38 (m, 1H) 6.01 (d, J=2.7 Hz, 1H) 6.36 (d, J=2.1 Hz, 1H) 7.33-7.43 (m, 2H) 7.43-7.51 (m, 1H) 7.53 (d, J=2.1 Hz, 1H) 8.26 (d, J=2.7 Hz, 1H) 10.78 (s, 1H).

Provenance & Evidence