HCID 57919339, compound → HCID 68995070, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(2,6-difluoro-phenyl)-propionic acid (Intermediate 34) and 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine (Intermediate 3) afforded N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(2,6-difluoro-phenyl)-propionamide as a light yellow solid (690 mg, 65%); ES+-HRMS m/e calcd for C30H33N5O4SiF4 [M+H+] 632.2311 found 632.2311. 1H NMR (300 MHz, DMSO-d6) δ ppm −0.08 (s, 6H) 0.80 (s, 9H) 3.24-3.34 (m, 1H) 3.49 (dd, J=14.5, 5.7 Hz, 1H) 3.83 (t, J=5.1 Hz, 2H) 4.00-4.10 (m, 2H) 5.69 (dd, J=9.8, 5.6 Hz, 1H) 5.89 (d, J=2.7 Hz, 1H) 6.43 (d, J=2.1 Hz, 1H) 6.96 (t, J=8.0 Hz, 2H) 7.18-7.52 (m, 4H) 7.54 (d, J=2.1 Hz, 1H) 8.20 (d, J=2.7 Hz, 1H) 10.67 (s, 1H).

Provenance & Evidence