HCID 57919097, compound → HCID 66898792, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-methyl-pentanoic acid (Intermediate 28) and 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine (Intermediate 3) afforded 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-methyl-pentanoic acid {1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-amide as an off-white solid (1.15 g, 68%); ES+-HRMS m/e calcd for C27H37N5O4SiF2 [M+H+] 562.2656 found 562.2658. 1H NMR (300 MHz, DMSO-d6) δ ppm −0.06 (s, 6H) 0.81 (s, 9H) 0.84-0.92 (m, 6H) 1.45 (m, 1H) 1.70-1.87 (m, 1H) 2.09-2.24 (m, 1H) 3.86 (t, J=5.1 Hz, 2H) 4.07 (t, J=5.1 Hz, 2H) 5.53 (dd, J=11.2, 4.2 Hz, 1H) 6.04 (d, J=2.7 Hz, 1H) 6.36 (d, J=2.0 Hz, 1H) 7.31-7.52 (m, 3H) 7.54 (d, J=2.0 Hz, 1H) 8.28 (d, J=2.7 Hz, 1H) 10.82 (s, 1H).

Provenance & Evidence