HCID 57919231, compound → HCID 86635178, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-ethyl-hexanoic acid (Intermediate 31) and 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (Intermediate 4) afforded 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-ethyl-hexanoic acid [1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-amide as a viscous oil as a mixture of diastereomers. 1H NMR (300 MHz, CDCl3) δ ppm 0.79-0.93 (m, 6H), 1.12 (br s, 1H), 1.20-1.54 (m, 4H), 1.34 (s, 3H), 1.38 (s, 3H), 2.02-2.19 (m, 1H), 2.19-2.34 (m, 1H), 3.68-3.77 (m, 1H), 4.04 (dd, J=8.6, 6.5 Hz, 1H), 4.10 (d, J=5.4 Hz, 2H), 4.32-4.47 (m, 1H), 5.66 (dd, J=9.1, 6.0 Hz, 1H), 6.00 (br s, 1H), 6.68 (s, 1H), 7.01-7.14 (m, 2H), 7.28-7.37 (m, 2H), 8.01 (d, J=2.7 Hz, 1H), 8.59 (br s, 1H).

Provenance & Evidence