Hydrochloric Acid → HCID 66875666, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-cyclopentyl-2-[4-(methyl-phenyl-amino)-6-oxo-6H-pyridazin-1-yl]-propionic acid methyl ester (66.3 mg, 0.18 mmol) in methanol (0.5 mL, 0.37M) was treated with a 4N aqueous sodium hydroxide solution (0.05 mL, 0.2 mmol) and was stirred at 25° C. overnight. After this time, the reaction was diluted with water (10 mL), acidified with a 1N aqueous hydrochloric acid solution and then was extracted into methylene chloride (3×25 mL). The combined organics were washed with a saturated aqueous sodium chloride solution (1×25 mL), dried over magnesium sulfate, filtered and concentrated in vacuo to afford 3-cyclopentyl-2-[4-(methyl-phenyl-amino)-6-oxo-6H-pyridazin-1-yl]-propionic acid (67.3 mg) as a viscous, yellow oil. This material was used without further purification.

Provenance & Evidence