HCID 57919168, compound → HCID 44463246, compound

Participants

Reaction Steps

Using the method described in Example 49, 3-cyclopentyl-2-[6-oxo-4-(2,3,6-trimethyl-phenoxy)-6H-pyridazin-1-yl]-propionic acid (Intermediate 66) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-[6-oxo-4-(2,3,6-trimethyl-phenoxy)-6H-pyridazin-1-yl]-propionamide as a white solid (1.27 g, 93%); ES+-HRMS m/e calcd for C28H37N5O4 [M+H+] 508.2919 found 508.2921. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.98-1.18 (m, 1H), 1.04 (s, 3H), 1.05 (s, 3H), 1.23-1.79 (m, 8H), 1.83-1.98 (m, 1H), 2.01 (s, 3H), 2.06 (s, 3H), 2.17-2.32 (m, 1H), 2.25 (s, 3H), 3.89 (s, 2H), 4.68 (s, 1H), 5.37-5.50 (m, 2H), 6.39 (d, J=2.1 Hz, 1H), 7.01-7.19 (m, 2H), 7.52 (d, J=2.1 Hz, 1H), 8.19 (d, J=2.7 Hz, 1H), 10.83 (s, 1H).

Provenance & Evidence