HCID 57919290, compound → HCID 57919135, compound

Participants

Reaction Steps

Using the method described in Example 49, 3-cyclopentyl-2-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 67) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclopentyl-2-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (1.13 g, 84%); ES+-HRMS m/e calcd for C29H37N5O5 [M+H+] 536.2868 found 536.2866. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.04 (br. s., 3H), 1.06 (br. s., 3H), 1.06-1.16 (m, 1H), 1.24-1.74 (m, 8H), 1.40 (s, 6H), 1.91 (br. s., 1H), 2.20-2.35 (m, 1H), 3.09 (s, 2H), 3.89 (s, 2H), 4.68 (s, 1H), 5.46 (dd, J=11.0, 4.1 Hz, 1H), 5.69 (d, J=2.7 Hz, 1H), 6.39 (d, J=2.1 Hz, 1H), 6.90 t, 7.5 Hz, 1H), 7.06 (d, J=7.5 Hz, 1H), 7.19 (d, J=7.5 Hz, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.11 (d, J=2.7 Hz, 1H), 10.84 (s, 1H).

Provenance & Evidence