2-[4-(2-tert-butyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-propionic acid → HCID 44465054, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2-tert-butyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-propionic acid (Intermediate 68) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(2-tert-butyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclopentyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide was obtained as an off-white solid (1.05 g, 77%); ES+-HRMS m/e calcd for C29H39N5O4 [M+H+] 522.3075 found 522.3077. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.03-1.08 (m, 8H), 1.32 (s, 9H), 1.37-1.78 (m, 7H), 1.81-2.02 (m, 1H), 2.17-2.36 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.47 (dd, J=10.7, 4.3 Hz, 1H), 5.79 (d, J=2.8 Hz, 1H), 6.40 (d, J=2.1 Hz, 1H), 7.16 (d, J=7.9 Hz, 1H), 7.23-7.30 (m, 1H), 7.31-7.38 (m, 1H), 7.50 (dd, J=7.8, 1.4 Hz, 1H), 7.53 (d, J=2.1 Hz, 1H), 8.15 (d, J=2.8 Hz, 1H), 10.81 (s, 1H).

Provenance & Evidence