HCID 57919213, compound → HCID 68991137, compound

HRID 2381515Notes

Reaction equation

HRID 2381515 reaction equation
[CH:1]1([O:5][C:6]2[CH:7]=[N:8][N:9]([CH:13]([CH2:17][CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[C:14]([OH:16])=O)[C:10](=[O:12])[CH:11]=2)[CH2:4][CH2:3][CH2:2]1.[CH3:23][C:24]1([CH3:36])[O:28][C@H:27]([CH2:29][N:30]2[CH:34]=[CH:33][C:32]([NH2:35])=[N:31]2)[CH2:26][O:25]1>>[CH:1]1([O:5][C:6]2[CH:7]=[N:8][N:9]([CH:13]([CH2:17][CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[C:14]([NH:35][C:32]3[CH:33]=[CH:34][N:30]([CH2:29][C@@H:27]4[CH2:26][O:25][C:24]([CH3:36])([CH3:23])[O:28]4)[N:31]=3)=[O:16])[C:10](=[O:12])[CH:11]=2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 57919213HCID 57919213, compound2×HCID 59344941(R)-1-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-3-amine2×

Product 1

HCID 68991137HCID 68991137, compound

Procedure

Using the method described in Example 49, 2-(4-cyclobutoxy-6-oxo-6H-pyridazin-1-yl)-3-cyclopentyl-propionic acid (Intermediate 72) and 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (Intermediate 4) afforded 2-(4-cyclobutoxy-6-oxo-6H-pyridazin-1-yl)-3-cyclopentyl-N-[1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-propionamide as an off-white solid as a mixture of diastereomers (0.38 g, 24%).

Sources & evidence

ORD record
ord-698e29e71fd845aa8975f8c0b81fc10f
Source dataset
uspto-grants-2012_09
Patent number
US08258134B2

Reaction notes

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