HRID2381516

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)C(CC1CCCC1)n1ncc(Oc2ncccc2F)cc1=O

HCID57919298

未命名化合物

2 次

HCID59344941

未命名化合物

2 次

PRODUCTS

生成物

结构：CC1(C)OC[C@@H](Cn2ccc(NC(=O)C(CC3CCCC3)n3ncc(Oc4ncccc4F)cc3=O)n2)O1

HCID68988443

未命名化合物

PROCEDURE

实验过程

Using the method described in Example 49, 3-cyclopentyl-2-[4-(3-fluoro-pyridin-2-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 73) and 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (Intermediate 4) afforded 3-cyclopentyl-N-[1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-2-[4-(3-fluoro-pyridin-2-yloxy)-6-oxo-6H-pyridazin-1-yl]-propionamide as a yellow solid as a mixture of diastereomers (1.29 g, 85%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2870f4b71d444552a4b93d81c7e804b0
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258134B2
来源说明: uspto-grants-2012_09

反应 SMILES

[CH:1]1([CH2:6][CH:7]([N:11]2[C:16](=[O:17])[CH:15]=[C:14]([O:18][C:19]3[C:24]([F:25])=[CH:23][CH:22]=[CH:21][N:20]=3)[CH:13]=[N:12]2)[C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:26][C:27]1([CH3:39])[O:31][C@H:30]([CH2:32][N:33]2[CH:37]=[CH:36][C:35]([NH2:38])=[N:34]2)[CH2:29][O:28]1>>[CH:1]1([CH2:6][CH:7]([N:11]2[C:16](=[O:17])[CH:15]=[C:14]([O:18][C:19]3[C:24]([F:25])=[CH:23][CH:22]=[CH:21][N:20]=3)[CH:13]=[N:12]2)[C:8]([NH:38][C:35]2[CH:36]=[CH:37][N:33]([CH2:32][C@@H:30]3[CH2:29][O:28][C:27]([CH3:39])([CH3:26])[O:31]3)[N:34]=2)=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5]1