HCID 57919243, compound → HCID 44464305, compound

Participants

Reaction Steps

Using the method described in Example 49, 3-cyclohexyl-2-[4-(2,4-dimethyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-propionic acid (Intermediate 89) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 3-cyclohexyl-2-[4-(2,4-dimethyl-phenoxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a light yellow solid (202 mg, 75%); ES+-HRMS m/e calcd for C28H37N5O4 [M+H+] 508.2919 found 508.2920. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.85-1.29 (m, 6H), 1.04 (s, 3H), 1.06 (s, 3H), 1.52-1.73 (m, 5H), 1.73-1.90 (m, 1H), 2.11 (s, 3H), 2.11-2.22 (m, 1H), 2.31 (s, 3H), 3.89 (s, 2H), 4.67 (s, 1H), 5.47-5.58 (m, 2H), 6.39 (d, J=2.1 Hz, 1H), 7.08 (d, J=8.2 Hz, 1H), 7.10-7.15 (m, 1H), 7.21 (s, 1H), 7.52 (d, J=2.1 Hz, 1H), 8.14 (d, J=2.7 Hz, 1H), 10.79 (s, 1H).

Provenance & Evidence