HCID 57919214, compound → HCID 44463772, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2-chloro-4-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclohexyl-propionic acid (Intermediate 90) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(2-chloro-4-methoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclohexyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as an off-white solid (190 mg, 63%); ES+-HRMS m/e calcd for C27H34N5O5Cl [M+H+] 544.2321 found 544.2324. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.88-1.22 (m, 6H), 1.05 (s, 3H), 1.06 (s, 3H), 1.62 (br. s., 5H), 1.74-1.88 (m, 1H), 2.06-2.24 (m, 1H), 3.81 (s, 3H), 3.89 (s, 2H), 4.67 (s, 1H), 5.53 (dd, J=11.2, 3.9 Hz, 1H), 5.65 (d, J=2.7 Hz, 1H), 6.39 (d, J=1.8 Hz, 1H), 7.04 (dd, J=9.0, 3.0 Hz, 1H), 7.27 (d, J=3.0 Hz, 1H), 7.43 (d, J=9.0 Hz, 1H), 7.52 (d, J=1.8 Hz, 1H), 8.18 (d, J=2.7 Hz, 1H), 10.83 (s, 1H).

Provenance & Evidence