HCID 57919217, compound → HCID 57919108, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2-chloro-4-trifluoromethoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclohexyl-propionic acid (Intermediate 91) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[4-(2-chloro-4-trifluoromethoxy-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-cyclohexyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide as a white solid (130 mg, 52%); ES+-HRMS m/e calcd for C27H31N5O5F3Cl [M+H+] 598.2039 found 598.2038. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.84-1.26 (m, 6H), 1.05 (br. s., 6H), 1.63 (br. s., 5H), 1.74-1.91 (m, 1H), 2.07-2.23 (m, 1H), 3.89 (s, 2H), 4.67 (s, 1H), 5.48-5.60 (m, 1H), 5.91 (d, J=2.7 Hz, 1H), 6.39 (s, 1H), 7.45-7.60 (m, 2H), 7.67 (dd, J=9.1, 2.1 Hz, 1H), 7.87 (br. s., 1H), 8.22 (d, J=2.7 Hz, 1H), 10.82 (s, 1H).

Provenance & Evidence