HCID 57919144, compound → HCID 66893974, compound

HRID 2381543Notes

Reaction equation

HRID 2381543 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([F:27])=[C:6]([C:23]([F:26])=[CH:24][CH:25]=1)[O:7][C:8]1[CH:9]=[N:10][N:11]([CH:15]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:16]([OH:18])=O)[C:12](=[O:14])[CH:13]=1)[CH3:2].[CH3:28][C:29]1([CH3:41])[O:33][C@H:32]([CH2:34][N:35]2[CH:39]=[CH:38][C:37]([NH2:40])=[N:36]2)[CH2:31][O:30]1>>[CH3:28][C:29]1([CH3:41])[O:33][C@H:32]([CH2:34][N:35]2[CH:39]=[CH:38][C:37]([NH:40][C:16](=[O:18])[CH:15]([N:11]3[C:12](=[O:14])[CH:13]=[C:8]([O:7][C:6]4[C:23]([F:26])=[CH:24][CH:25]=[C:4]([O:3][CH2:1][CH3:2])[C:5]=4[F:27])[CH:9]=[N:10]3)[CH2:19][CH:20]([CH3:21])[CH3:22])=[N:36]2)[CH2:31][O:30]1

Participants

3

Reactant 2

HCID 57919144HCID 57919144, compound2×HCID 59344941(R)-1-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-3-amine2×

Product 1

HCID 66893974HCID 66893974, compound

Procedure

Using the method described in Example 49, 2-[4-(3-ethoxy-2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-methyl-pentanoic acid (Intermediate 92) and 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (Intermediate 4) afforded 2-[4-(3-ethoxy-2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-4-methyl-pentanoic acid [1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-amide as an off-white solid as a mixture of diastereoisomers (164 mg, 78%).

Sources & evidence

ORD record
ord-83888937a0634dc3b40a8f02d8942a6c
Source dataset
uspto-grants-2012_09
Patent number
US08258134B2

Reaction notes

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