HCID 57919311, compound → HCID 68989527, compound

HRID 2381544Notes

Reaction equation

HRID 2381544 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([F:30])=[C:6]([C:26]([F:29])=[CH:27][CH:28]=1)[O:7][C:8]1[CH:9]=[N:10][N:11]([CH:15]([CH2:19][CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:16](O)=[O:17])[C:12](=[O:14])[CH:13]=1)[CH3:2].[CH3:31][C:32]1([CH3:44])[O:36][C@H:35]([CH2:37][N:38]2[CH:42]=[CH:41][C:40]([NH2:43])=[N:39]2)[CH2:34][O:33]1>>[CH3:31][C:32]1([CH3:44])[O:36][C@H:35]([CH2:37][N:38]2[CH:42]=[CH:41][C:40]([NH:43][C:16](=[O:17])[CH:15]([N:11]3[C:12](=[O:14])[CH:13]=[C:8]([O:7][C:6]4[C:26]([F:29])=[CH:27][CH:28]=[C:4]([O:3][CH2:1][CH3:2])[C:5]=4[F:30])[CH:9]=[N:10]3)[CH2:19][CH:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)=[N:39]2)[CH2:34][O:33]1

Participants

3

Reactant 2

HCID 57919311HCID 57919311, compound2×HCID 59344941(R)-1-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-3-amine2×

Product 1

HCID 68989527HCID 68989527, compound

Procedure

Using the method described in Example 49, 2-[4-(3-ethoxy-2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(tetrahydro-pyran-4-yl)-propionic acid (Intermediate 93) and 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (Intermediate 4) afforded N-[1-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-2-[4-(3-ethoxy-2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(tetrahydro-pyran-4-yl)-propionamide as an off-white solid as a mixture of diastereoisomers (138 mg, 55%).

Sources & evidence

ORD record
ord-a36794417c12413994ce7225e7ce37ff
Source dataset
uspto-grants-2012_09
Patent number
US08258134B2

Reaction notes

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