HCID 57919099, compound → HCID 57919254, compound

Participants

Reaction Steps

Using the method described in Example 49 from 2-[5-chloro-4-(2-chloro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(tetrahydro-pyran-4-yl)-propionic acid (Intermediate 96) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-[5-chloro-4-(2-chloro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-3-(tetrahydro-pyran-4-yl)-propionamide (354 mg); ES+-HRMS m/e calcd for C25H29N5O5Cl2 [M+H+] 550.1619 found 550.1622. 1H NMR (300 MHz, CDCl3) δ ppm 1.17 (s, 6H), 1.22-1.55 (m, 4H), 1.55-1.77 (m, 2H), 2.10-2.25 (m, 2H), 3.24-3.41 (m, 2H), 3.86-3.96 (m, 2H), 3.98 (s, 2H), 5.75 (t, J=7.5 Hz, 1H), 6.65 (d, J=1.8 Hz, 1H), 7.23-7.26 (m, 1H), 7.29-7.35 (m, 2H), 7.35-7.43 (m, 1H), 7.49 (s, 1H), 7.54 (d, J=7.8 Hz, 1H), 8.74 (br. s., 1H).

Provenance & Evidence