HCID 57919133, compound → HCID 57919279, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(tetrahydro-pyran-4-yl)-propionic acid (Intermediate 32) and acetic acid 2-(3-amino-5-methyl-pyrazol-1-yl)-1-methyl-ethyl ester (Intermediate 98) afforded acetic acid 2-{3-[2-[4-(2,6-difluoro-phenoxy)-6-oxo-6H-pyridazin-1-yl]-3-(tetrahydro-pyran-4-yl)-propionylamino]-5-methyl-pyrazol-1-yl}-1-methyl-ethyl ester as a mixture of diastereomers (180 mg, 39%); ES+-HRMS m/e calcd for C27H31N5O6F2 [M+H+] 560.2315 found 560.2313. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.09-1.45 (m, 4H), 1.17, 1.18 (2×d, J=6.4 Hz, 3H), 1.45-1.58 (m, 2H), 1.77-1.92 (m, 1H), 1.94, 1.95 (2×s, 3H), 2.22 (s, 3H), 3.09-3.28 (m, 2H), 3.73-3.86 (m, 2H), 3.97-4.14 (m, 2H), 5.01-5.18 (m, 1H), 5.53 (dd, J=10.7, 3.2 Hz, 1H), 6.04 (d, J=2.3 Hz, 1H), 6.21 (s, 1H), 7.33-7.43 (m, 2H), 7.44-7.54 (m, 1H), 8.29 (d, J=2.3 Hz, 1H), 10.75, 10.77 (2×s, 1H).

Provenance & Evidence