HCID 57919275, compound → HCID 57919336, compound

Participants

Reaction Steps

Using the method described in Example 49, 2-(5-chloro-6-oxo-4-phenoxy-6H-pyridazin-1-yl)-3-cyclohexyl-propionic acid (Intermediate 102) and 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (Intermediate 1) afforded 2-(5-chloro-6-oxo-4-phenoxy-6H-pyridazin-1-yl)-3-cyclohexyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide (136 mg); ES+-HRMS m/e calcd for C26H32N5O5Cl [M+H+] 514.2216 found 514.2214. 1H NMR (300 MHz, CDCl3) δ ppm 0.72-0.98 (m, 2H), 1.09 (br. s., 10H), 1.47-1.80 (m, 5H), 1.88-2.16 (m, 2H), 3.87 (s, 2H), 5.68 (dd, J=8.6, 6.2 Hz, 1H), 6.62 (s, 1H), 7.08 (d, J=7.8 Hz, 2H), 7.20-7.29 (m, 2H), 7.30-7.47 (m, 2H), 7.52 (s, 1H), 8.51 (s, 1H).

Provenance & Evidence