Thionyl Chloride → HCID 59824783, compound

Participants

Reaction Steps

2-Benzyl-3-hydroxy-3-[4-(2-trimethylsilanylethoxymethoxy)phenyl]-2,3-dihydroiso-indol-1-one (125 mg, 0.27 mmol) was reacted with thionyl chloride (0.019 mL, 0.27 mmol) and a catalytic amount of DMF (3 drops) as for general procedure G. Removal of the solvent gave 2-benzyl-3-chloro-3-[4-(2 trimethylsilanylethoxymethoxy)phenyl]-2,3-dihydroiso-indol-1-one as a colourless oil (129 mg, 0.27 mmol, 100%).

Provenance & Evidence