反应详情

2-(4-Chlorobenzyl)-3-(4-chlorophenyl)-3-hydroxyisoindolinone (150 mg, 0.390 mmol.) was reacted with thionyl chloride (0.031 mL, 0.429 mmol.) and a catalytic amount of DMF as for general procedure B, and the solvent removed to give a colourless oil of the crude 3-chloro-2-(4-chlorobenzyl)-3-(4-chlorophenyl)isoindolin-1-one (157 mg, 0.390 mmol., 100%).

1. customa catalytic amount of DMF as for general procedure B, and the solvent removed