HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 2,4-Dichloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 14116871 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Dichloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidine | HCID 57415902 | 54.1% |
Reaction Steps
To a suspension of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (2.0 g, 10.6 mmol) in DCM (32 mL) was added NIS (2.4 g, 10.6 mmol) at room temperature. After stirring for 1 h, the resulting precipitate was collected by filtration to give 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258144B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-64eaa55a72444a9fb0a4751c508a97fa |
| Source note | uspto-grants-2012_09 |