HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 2,4-Dichloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 14116871 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Dichloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidine | HCID 57415902 | 55.7% |
Reaction Steps
To a suspension of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (3.00 g, 16.0 mmol) in CH2Cl2 (30 mL), N-iodosuccinimide (3.60 g, 16.0 mmol) was added. It was stirred at room temperature for 20 h. The fine precipitate was collected, dried on vacuum to give 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (2.80 g). MS 314.1 and 316.1 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258144B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-aa8e0bed0f0346479dc0e0c8a0e3016c |
| Source note | uspto-grants-2012_09 |